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And the functions of the CB receptors
The Endocannabinoid System
CB-1
Mental Health
(CB-1 G-protein coupled cannabinoid receptor 1) Responsible for the euphoric and anti-conclusive eects of cannabis. Reduces pain and inammation. Has an effect on many neuronal signaling pathways. Primarily found in the brain- in basal ganglia, limbic system (hippocampus), but also found in cerebellum and female/male reproductive systems. Absent in the medula oblangata (brain stem) which is responsible for cardiovascular and respiratory functions.
CBD
- Not psychoactive
- Anti-spasmadic (helps manage spasms)
- Anxiolytic (eases anxiety/panic attack/post traumatic stress)
- Anti-inflammatory
- Antagonist to GPR-55 receptor, (has an effect on cell cytoskeleton, bone function, and other processes)
- Anti epileptic
- Neuroprotective
- Vasorelaxant
- Antispasmadic
- Anti-ischemic
- Anti proliferative
- Immunosuppressive
- Anxiolytic
- Anti-psychotic
- Anticancer
- Anti-emetic
- Antibacterial
- Anti-diabetic
- Anti-psoriatic
- Intestinal anti-pro kinetic
- Analgesic
CBG
- Anti-inflammatory
- Bone-stimulant
- Anti-bacterial
- Anti-proliferative
- Has some affinity for CB-2
- Shown to relieve intraocular pressure (treats glaucoma)
- Non psychoactive, however acts as an 5-HT1A receptor antagonist, and CB1 antagonist
CBC
- May contribute to the anti-viral effects of cannabis.
- Anti-proliferative (anti-cancer)
- Anti-inflammatory
- Bone-stimulant
- Antimicrobial (pain relief)
- May also contribute to analgesic effects.
CB-2
Body Health
(CB-2 G-protein coupled cannabinoid receptor 2) Closely related to CB-1 Has an eect on Cytokine release, which is utilized in the autocrine, paracrine, and endocrine system, as well as chemotaxis. (chemotaxis is how the somatic cells direct their movement within the body. This is important foor cancer treatment, cancer cells usually have problems within chemotaxis) May help treat Alzheimer’s disease This all relates to your body’s immune system. This could mean, anti-bacterial, anti-fungal, & even anti-cancer or auto-immune diseases!
THC-9
- Delta9-THC is the principal psychoactive
- constituent of cannabis
- Analgesic (pain killer)
- Anti-inflammatory
- Anti-emetic (eases nausea)
- Euphoriant (makes you happy)
- Apperite stimulant
- Anti-spasmadic (suppresses muscle spasms)
- Affects CB-1 receptors in the brain and GPR-55 receptor
CBN
- Mildly psychoactive
- Sedative
- Anti-convulsant
- Anti-biotic
- Anti-insomnia (sleep aid)
- Anti-inflammatory
- Anti-spasmodic
- Primary product of THC degradation (THC molecule breaks down into CBN)
- Binds to CB-1 & CB-2receptors, with higher affinity for CB-2
- Similar properties to THC, with relatively less affinity for CB-1 receptors.
THC-V
- Bone stimulant
- Anti-epileptic (reduces seizure)
- Anorectic (appetite suppressant)
- Anti-oxidant (soaks up free radicals)
- May play a future role in treating obesity and cardiometabolic diseases
- Possible treatment for Parkinson’s like diseases
- Associated with the fragrance of the plant somewhat ‘softens’ the effect of THC-9 by antagonizing CB-1 receptors, this would make the effects of the CB-2 and other receptors more prevalent.
